Search
Latest topics
Log in
Exhaust fumes linked to rise in heart disease
4 posters
Page 1 of 1
Exhaust fumes linked to rise in heart disease
Exhaust fumes linked to rise in heart disease
· Particles may trigger hardening of arteries
· Study offers explanation for leading cause of death
Pollution from motor vehicles may be driving up rates of heart disease by triggering inflammation and hardening blood vessels, scientists warn today. Researchers found that fine particles released in exhaust fumes combine with natural fats in arteries to spark a cascade of genetic changes which are capable of inducing cardiovascular atherosclerosis, the leading cause of death in the western world.
The finding points to an underlying explanation for the significant rise in hospital admissions and deaths from heart disease that coincides with greater levels of pollution. Previous studies have shown that when levels of airborne particles rise by 10 micrograms per cubic metre, deaths from one form of heart disease rise 6%.
Arteries begin to harden when fats circulating in the bloodstream get trapped in the blood vessel walls and begin to deteriorate through oxidation. But scientists at the University of California in Los Angeles suspected that airborne pollution may be responsible for exacerbating the damage. The team, led by Andre Nel, an expert on the health effects of pollutants, took cells from the walls of human blood vessels and exposed them to diesel exhaust particles at levels equivalent to those found in cities. Some of the cells were exposed to blood vessel fats at the same time.
When the scientists screened the cells to see how their genes had reacted to the exposure, they found that 1,555 genes had been made more than 1.5 times more active in the cells. The effect was more pronounced when the cells were exposed to diesel particles and the fatty deposits. Further analysis revealed that most of the boosted genes belonged to three distinct groups that all play crucial roles in arterial blood vessel disease.
Studies in mice confirmed that breathing in fine particles from exhaust fumes triggered the genetic changes that drive heart disease. Previous experiments with the animals have already confirmed that exposure to diesel particles increased their risk of developing hardened arteries.
Writing in the journal Genome Biology today, the scientists say it is not clear how the pollutants trigger the genetic changes, but suggest the chemicals that coat the particles could be to blame. Tests on diesel particles have revealed their surfaces to be rich in a range of potentially toxic compounds, ranging from organic hydrocarbons to sulphates and nitrates.
In February, a study of 65,000 women living in 36 cities across the US found that those living in high pollution areas were at an increased risk of heart disease, stroke and death. The study, published in one of the world's leading medical journals, pointed to fine particles from traffic fumes, coal-fired power stations and wood fires as the culprits.
· Particles may trigger hardening of arteries
· Study offers explanation for leading cause of death
Pollution from motor vehicles may be driving up rates of heart disease by triggering inflammation and hardening blood vessels, scientists warn today. Researchers found that fine particles released in exhaust fumes combine with natural fats in arteries to spark a cascade of genetic changes which are capable of inducing cardiovascular atherosclerosis, the leading cause of death in the western world.
The finding points to an underlying explanation for the significant rise in hospital admissions and deaths from heart disease that coincides with greater levels of pollution. Previous studies have shown that when levels of airborne particles rise by 10 micrograms per cubic metre, deaths from one form of heart disease rise 6%.
Arteries begin to harden when fats circulating in the bloodstream get trapped in the blood vessel walls and begin to deteriorate through oxidation. But scientists at the University of California in Los Angeles suspected that airborne pollution may be responsible for exacerbating the damage. The team, led by Andre Nel, an expert on the health effects of pollutants, took cells from the walls of human blood vessels and exposed them to diesel exhaust particles at levels equivalent to those found in cities. Some of the cells were exposed to blood vessel fats at the same time.
When the scientists screened the cells to see how their genes had reacted to the exposure, they found that 1,555 genes had been made more than 1.5 times more active in the cells. The effect was more pronounced when the cells were exposed to diesel particles and the fatty deposits. Further analysis revealed that most of the boosted genes belonged to three distinct groups that all play crucial roles in arterial blood vessel disease.
Studies in mice confirmed that breathing in fine particles from exhaust fumes triggered the genetic changes that drive heart disease. Previous experiments with the animals have already confirmed that exposure to diesel particles increased their risk of developing hardened arteries.
Writing in the journal Genome Biology today, the scientists say it is not clear how the pollutants trigger the genetic changes, but suggest the chemicals that coat the particles could be to blame. Tests on diesel particles have revealed their surfaces to be rich in a range of potentially toxic compounds, ranging from organic hydrocarbons to sulphates and nitrates.
In February, a study of 65,000 women living in 36 cities across the US found that those living in high pollution areas were at an increased risk of heart disease, stroke and death. The study, published in one of the world's leading medical journals, pointed to fine particles from traffic fumes, coal-fired power stations and wood fires as the culprits.
Re: Exhaust fumes linked to rise in heart disease
It was always meant to cause problems. Now new one to add to the list
strangebeauty- Active Member
- Number of posts : 219
Age : 36
Registration date : 2007-07-30
Character sheet
sg: zseg
Re: Exhaust fumes linked to rise in heart disease
gud,
tnx for sharing
tnx for sharing
Admin- Admin
- Number of posts : 344
Registration date : 2007-07-08
Character sheet
sg: zseg
Re: Exhaust fumes linked to rise in heart disease
thanx for shaering this
Geo91- Admin
- Number of posts : 445
Age : 32
Localisation : UK
Registration date : 2007-07-30
Character sheet
sg: zseg
Page 1 of 1
Permissions in this forum:
You cannot reply to topics in this forum
Fri Aug 10, 2007 3:34 pm by Admin
» owning thread
Wed Aug 08, 2007 10:09 am by Geo91
» From Locked
Wed Aug 08, 2007 3:33 am by Admin
» How to Improve Your Memory Power
Tue Aug 07, 2007 11:31 am by strangebeauty
» 10 Essential Health Tips
Tue Aug 07, 2007 11:27 am by strangebeauty
» Olmert hopes talks can lead to Palestinian state
Mon Aug 06, 2007 9:15 pm by strangebeauty
» Love Poems---Attractive!!!
Mon Aug 06, 2007 9:02 pm by strangebeauty
» Remember
Mon Aug 06, 2007 9:00 pm by strangebeauty
» Lost
Mon Aug 06, 2007 8:59 pm by strangebeauty